Cycling of O-linked [beta]-N-acetylglucosamine on nucleocytoplasmic proteins
Article Abstract:
Studies conducted shows that O-GlcNAc cycling is tightly regulated by the concerted actions of two highly conserved enzymes, serine and threonine, which serves as a nutrient and stress sensor. The interplay between O-GlcNAc and O-phosphate is found to be critical for the aetiology of neurodegenerative disease as well as to the functions and turnover of oncoproteins tumour suppressors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
Article Abstract:
The role of genome instability and p53 in AID-induced c-myc-Igh translocations is discussed. It is shown that the translocations are inhibited by the tumor suppressor p53 and that the accumulation of AID-dependent, Igh associated chromosomal lesions is not sufficient to enhance c-myc-Igh translocations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Adaptive immunity maintains occult cancer in an equilibrium state
Article Abstract:
The occurrence of cancer immunoediting equilibrium process is demonstrated using a mouse model. The immune system of a naive mouse restrains cancer growth for extended time periods along with destroying tumour cells and graving tumour immunogenicity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effects of elevated atmospheric carbon dioxide on insect-plant interactions. Local Species Richness of Leaf-Chewing Insects Feeding on Woody Plants from One Hectare of a Lowland Rainforest
- Abstracts: Quantification of actinide [alpha]-radiation damage in minerals and ceramics. Another continental pool in the terrestrial silicon cycle
- Abstracts: Highly controlled acetylene accommodation in a metal-organic microporous material. Gas in a straitjacket
- Abstracts: Tales of the expected. Conceits and provocations. Down and out
- Abstracts: Effect of hypoxia on opercular displays: Evidence for an honest signal? The net effects of guarding on egg survivorship in the flagfish, Jordanella floridae